ea0090oc4.2 | Oral Communications 4: Reproductive and Developmental Endocrinology | ECE2023
Hjorth Andreassen Christine
, Mortensen Li Juel
, Holt Rune
, Knudsen Nadia Krarup
, Nielsen John Erik
, Juul Anders
, Jorgensen Anne
, Jensen Martin Blomberg
Currently, no treatment options exist to improve semen quality for the majority of infertile men. Proper interaction between germ and Sertoli cells in the testis is critical for sperm production, and a recent study suggested that Denosumab, an inhibitor of RANKL signaling, may stimulate sperm production in some infertile men. Here, we show in animal and human studies how expression of the RANKL signaling system is critical for both Sertoli cell function and the testicular resp...